With more information available on-line, more technologies available for users to access information virtually, and more interdisciplinary research shaping our collection, librarians are facing more challenges than before. For instance, how can we penetrate users’ information search life and help them find what they want in numerous information resources that have ever-changing search interfaces and features? How do we shape our users’ chemical information literacy in the e-resources environment? On the other hand, to what degree can we partner with users, especially faculty members, to provide the customized information services and collections that they need? The USC Chemistry Outreach and Information Literacy Program (OIL) serves to reach out to users and to collaborate with faculty members to provide customized, systemic, broad, and in-depth information literacy training (e.g. research group, course-related, project-related). This presentation will answer the questions posed above and offer some best practices in sustainable chemical information education.