This paper describes a long-standing collaboration between the University of Pennsylvania’s chemistry librarian and the instructors of the advanced undergraduate laboratory course. The chemistry librarian teaches the students two intense lectures, complete with credit-bearing assignments, that teach them to use the chemical information resources. The first lecture and assignment review the structure of the chemical literature and teach the students to find physical properties and preparations of substances. The second lecture teaches students techniques of text and structure searching using truncation, preparing them to use the chemical information resources to answer open-ended questions, exemplified in the accompanying assignment.