| High-throughput screening (HTS) can be used as a cross-disciplinary tool to bridge medicinal chemistry and drug discovery biology for efficient knowledge creation and utilization. This presentation focuses on the practical aspects of compound management, biological assay design and implementation, data management, and productive communication. Based on a few discovery programs at Incyte, the presentation illustrates how to effectively integrate different components of HTS into the drug discovery process to maximize HTS utility. The value creation is exclusively evaluated by medicinal chemists and ultimately by measurable contribution to the preclinical candidates. The topics range from how to apply a high-throughput mode of inhibition determination method to how to minimize redundant interaction by communicating directly with corporate database and automatically triggering downstream assay requests. |